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Wuhan Chemstan Biotechnology Co., Ltd.

武漢科斯坦生物科技有限公司

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產品名稱:

Sarilumab

NO.
009
貨號:
CSD00271
中文名稱
/
英文名詞
Sarilumab
CAS號
1189541-98-7
產品貨號:
CSD00271
貨期:
現貨
價格與訂購:
2480.00
數量
-
+
庫存:
300
沒有此類產品
產品信息
如何訂購

貨號(Catalog No.)

CSD00271

通用名INN

Sarilumab

純度(Purity)

>95%

濃度( Concentration)

1mg/ml

Formulation

PBS buffer PH7.5

Source

CHO cells

內毒素(Endotoxin level)

Please contact with the lab for this information.

生物活性

產品描述(Description)

Sarilumab is a fully human anti-IL-6R monoclonal IgG1 antibody that binds to both membrane bound and soluble interleukin 6 (IL-6) receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6 1. Sarilumab was developped by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approved in May 2017 and followed by EU approval in June 2017 for the treatment of moderate to severe Rheumatoid Arthritis (RA) in combination with methotrexate 4. RA is a chronic inflammatory disease characterized by polyarthritis and its treatment has been challenged by the different response in every patient 3. Subcutaneous administration of Sarilumab has been shown to decrease acute-phase reactant levels and improve in clinical RA symptoms 2.

別名(Alternative names)

REGN88,SAR153191

靶點;物種(Specificity target name;species)

IL6R/CD126[Homo sapiens]

種類(Species)

Homo sapiens

受體鑒定(Receptor identification)

IgG1-kappa

化學信息

分子量(MV)


150000.0 Da (143900 Da in absence of N-glycosylation in heavy chains (Asn296) )

CAS

1189541-98-7

存儲條件(Storage)

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.

Note

For research use only .

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